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Study Finds Correlations Between Synovial Tissue & Gene Expression

The Rheumatologist featured a study by HSS rheumatologist Dana E. Orange, MD, who reviewed the gene expression analysis of synovial tissue from patients with rheumatoid arthritis (RA).

According to Dr. Orange, no reliable biomarkers exist to predict therapeutic response in RA patients.

Dr. Orange and a team of researchers examined samples from RA patients undergoing arthroplasty.

"Maybe for patients who aren't responding the way we normally think they should and have no inflammation in their blood, a synovial biopsy might help to define the right treatment approach. We're also very interested in developing blood and imaging biomarkers of the synovial subtypes so patients won't need to undergo synovial biopsy," she said.

Read the full article at the-rheumatologist.org.