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Revision TKR for infection, fracture doubles risk for venous thromboembolism

Orthopedics Today reports on an HSS study led by rheumatologist Anne R. Bass, MD, which found revision for periprosthetic joint infection or fracture doubles the risk for postoperative venous thromboembolism (VTE) compared with aseptic revision total knee replacement (TKR).

Researchers analyzed 25,441 New York residents (mean age of 66 years) who underwent revision TKR from 1998 to 2014. According to the study, the most common indication for revision TKR was aseptic for 69% of patients (n = 17,563). The remaining 28% and 3% of patients were indicated for revision TKR due to infection (n = 7,075) and fracture (n = 803), respectively.

Overall, 2.8% of patients (n = 719) had VTE within 90 days following surgery, with 1.5% of patients (n = 387) experiencing VTE during admission for the revision procedure. They found the 90-day incidence of VTE was 2.1% after aseptic revision, was 4.3% after revision for infection and was 5.9% after revision for fracture. They determined the adjusted odds ratio for VTE relative to aseptic revision was 2.01 for septic revision TKR and 2.62 for fracture. Researchers also noted a history of VTE was a “strong risk factor” for VTE following revision TKR.

Read the full article at Healio.com/news/orthopedics.