In Small Study, CAR-T Therapy Pushes Lupus Into Remission
HealthDay reports on study results published in Nature Medicine showing CAR-T therapy may kick hard-to-treat lupus into remission and includes commentary from HSS rheumatologist Ruth Fernandez Ruiz, MD, MS, who was not involved in the study.
The study included five people with severe lupus involving multiple organs — such as the kidneys, heart, lungs and joints — who hadn't responded to standard therapy.
According to Dr. Fernandez Ruiz, “[Lupus] patients had striking clinical improvement after CAR-T cell therapy and experienced clinical remission while off... [the] drugs for the duration of follow-up after CAR-T cell therapy. Despite the limited sample size, it is likely that there will be a role in implementing CAR-T cell therapy in [lupus], particularly for patients with severe disease that is refractory [resistant] to standard-of-care treatments.”