“We have found that robotic assistance leads to improved implant positioning, alignment and ligament balance, which enable us to better replicate the patient’s natural anatomy,” said David J. Mayman, MD, chief of the Adult Reconstruction and Joint Replacement Service at HSS. “With our vast registry of patient data and strong commitment to research, HSS is in a unique position to continue leading the evolution of robotic assistance in the operating room.”

The first study found that the use of a surgical robot during total knee replacement surgery reduced the need for manipulation under anesthesia (MUA), an outpatient procedure that may be prescribed when physical therapy (PT) after surgery becomes too painful for the patient due to joint stiffness caused by scar tissue. During the course of care, approximately 3.5% of knee replacement patients undergo MUA, according to Seth A. Jerabek, MD, hip and knee surgeon at HSS and co-author of this study, typically within 90 days of their surgery. After MUA, patients are typically better able to participate in PT and progress in their recovery.

Investigators at HSS set out to determine if the use of computer navigation or robotic-arm assistance during surgery reduced the need for MUA. Previous studies have shown that the use of either tool leads to a more precise knee replacement.

The HSS researchers conducted a retrospective chart review of 21,893 knee replacement surgeries performed between April 2008 and December 2022. They found that the use of the robotic arm or computer navigation led to a significant decrease in the number of patients who needed MUA after surgery (2.7% of patients with robotic-assisted surgery; 2.8% of patients whose surgery was performed with computer navigation; 3.7% of patients whose surgery was performed without either technology).

“These results highlight the potential benefits of incorporating technological advancements into knee replacement surgery, offering improved outcomes and reducing the need for additional interventions such as MUA,” Dr. Jerabek said.

The second study compared short-term outcomes of the anterior versus the posterior approach in robotic-assisted total hip replacement (THR) surgery. “There is no consensus on which approach has a lower risk of postoperative complications,” said Elizabeth B.  Gausden, MD, MPH, a hip and knee surgeon at HSS and principal investigator of the study. “This can often lead to confusion on the part of the patient as to which approach may be best for them. Our objective was to compare rates of dislocation, re-operation, revision and patient-reported outcome measures of each approach performed with robotic assistance.”

Dr. Gausden and colleagues identified 2,040 consecutive robotic-assisted THRs for osteoarthritis in the HSS patient registry between 2017 and 2020. A total of 497 hip replacements were performed using the anterior approach; 1,542 were performed with the posterior approach.

At mean follow-up of 18 months, the researchers found no difference in the rate of dislocation, re-operation or revision surgery between the two approaches. At early follow-up of six weeks, the anterior approach was associated with a somewhat faster functional recovery. By 3 months following the THA, there were no longer significant differences between patients who had different approaches. “The take-home message is that hip replacement has excellent outcomes with each respective approach when performed by surgeons with extensive experience in that approach,” Dr. Gausden said. “While the goal of the study was not to compare robotic THA to manual THA, it is likely that the very low incidence of instability or dislocation overall can be attributed to the use of robotic technology for planning and execution.”

"As the use of robotic assistance in joint replacement surgery becomes more common, future studies should evaluate outcomes over longer periods of time,” concluded Dr. Mayman. “As a leader in the use of this technology, HSS continues to study various robotic systems to acquire the data needed to provide the evidence-based care that will benefit our patients.”  

References:

Robotic-assisted Total Knee Arthroplasty Is Associated with Decreased Manipulation under Anesthesia Compared to Manual Approach

Authors: Cale Pagan; David J. Mayman, MD; Douglas E. Padgett, MD; Jonathan M. Vigdorchik, MD; Peter K. Sculco, MD; Seth A. Jerabek, MD; Theofilos Karasavvidis, MD (HSS).

Program Number: P153 – February 14, 2024

Comparison of Short-Term Outcomes Between Direct Anterior and Posterolateral Approach in Robotic-Assisted Total Hip Arthroplasty

Authors: Nikhil Vasireddi, MHA (Case Western); Sonia Chandi, MD; Colin Neitzke; Agnes Cororaton, MS; Jason L. Blevins, MD; Jonathan M. Vigdorchik, MD; Alexander S. McLawhorn, MD, MBA; Elizabeth B. Gausden, MD, MPH (HSS).

Program Number: e076 – February 12, 2024

Dr. Mayman will succeed Mathias P. Bostrom, MD, who, along with sports medicine surgeon Answorth A. Allen, MD, was recently appointed Associate Surgeon-in-Chief at HSS after serving as ARJR chief for the past four years. Dr. Green will succeed Roger F. Widmann, MD, who has led the Pediatric Surgical Service since 2004. Dr. Widmann will continue to care for pediatric patients with spine and limb deformities and will lead a new center of excellence dedicated to robotic-assisted surgery at HSS. Both appointments will go into effect September 5.

“We are grateful to Drs. Bostrom and Widmann for their steadfast leadership over the years,” said Bryan T. Kelly, MD, MBA, president, surgeon-in-chief and medical director of HSS. “Drs. Mayman and Green are not only talented surgeons, they are collaborative leaders who bring a wealth of expertise and experience to their new roles. These appointments will allow us to continue to advance excellence for our joint replacement and pediatric surgical patients.”

In their new roles, Drs. Mayman and Green will each lead highly integrated multidisciplinary teams. The ARJR service is comprised of programs focused on hip and knee osteoarthritis and other problems requiring joint replacement in adults, while Pediatrics covers the spectrum of conditions requiring orthopedic surgery in children, ranging from sports medicine injuries and trauma to congenital issues of the spine and hip.

David Mayman

David J. Mayman, MD, is an orthopedic surgeon specializing in hip and knee replacements. A member of the Hip and Knee Societies, Dr. Mayman is a leader in the field of robotic and navigated joint replacement surgery. His primary research interest lies in incorporating new technologies into arthroplasty, with the goal of achieving more favorable outcomes for patients.

“I’m honored to take on this new role, leading and collaborating with a deeply talented team of surgeons in order to deliver scientific breakthroughs and address joint pain challenges,” said Dr. Mayman. “HSS is recognized as the leader in joint replacement, and by harnessing the power of our musculoskeletal expertise, we will advance the overall health and wellness of generations to come.” 

Daniel Green

Daniel W. Green, MD, MS, is a pediatric orthopedic surgeon specializing in knee surgery.

A holder of the Mary Kathryn and Alexander Navab Chair for Pediatric Orthopedic Research at HSS, Dr. Green’s clinical research has focused on surgical outcomes and techniques used to treat patella dislocation, osteochondritis dissecans, discoid meniscus and pediatric ACL tears.

“I am honored to be asked to represent such a talented group of pediatric orthopedic surgeon leaders dedicated to taking care of children at the hospital ranked no. 1 in the world for orthopedics,” said Dr. Green. “We are positioned to maintain our leadership position as national and international thought leaders and dedicated to increasing access to our care.”

“HSS is home to an unparalleled number of talented and knowledgeable experts who specialize in caring for patients with various conditions throughout the lifespan,” said Louis A. Shapiro, CEO of HSS. “These appointments highlight the depth of leadership and experience across each area of the organization.”
 

 Three studies focus on how to optimize total knee arthroplasty (TKA) surgery using biomechanics and computer modeling, while another study discusses how three-dimensional (3-D) modeling can improve total hip arthroplasty (THA).

 What follows are some highlights from the meeting:

Undersizing Tibial Baseplates in Cementless TKA Has Negative but Small Impact for Bone–Implant Interaction: A Computational Biomechanical Study

Computational biomechanical modeling is useful for taking a closer look at how making changes to orthopedic surgery techniques affects patient outcomes. A study led by Fernando J. Quevedo-González, PhD, assistant scientist in the Department of Biomechanics at HSS, and HSS hip and knee surgeon Jonathan M. Vigdorchik, MD, used these kinds of models to determine how best to minimize the risk of complications in cementless TKA. The model was developed using preoperative scans from 12 female patients about to undergo robotic TKA and was used to ask questions about how sizing the tibial baseplate (the metal part of the prosthesis that connects to the shin bone) affects outcomes. The investigators found that, in general, decreasing the size of the baseplate increased the amount of bone at risk of failure, but this risk was small compared with normal variability of bone quality among patients and how their individual knee joints were loaded as they used their knee in performing activities of daily living. Based on this result, they concluded that baseplate undersizing can be done to optimize the placement of the tibial component of the TKA without increasing the risk of bone failure.

Authors: Fernando J. Quevedo-González, PhD, Peter K. Sculco, MD, Cynthia Kahlenberg, MD, Joseph D. Lipman, MS, Timothy M. Wright, PhD, Jonathan M. Vigdorchik, MD.

Posterior Tibial Slope in Total Knee Arthroplasty: The Transmalleolar Sagittal Axis Underestimates Slope Compared to Traditional Intramedullary Axis

The tibial slope, one of multiple angles used to place a TKA, defines how the tibial component meets the knee and impacts the knee’s ability to bend and the strain that’s put on the ligaments throughout range of motion. A study led by HSS hip and knee surgeons Brian P. Chalmers, MD, and Steven B. Haas, MD, looked at how robotics and computer navigation influence the tibial slope in TKA. Historically, knee implants were designed using what is called the intramedullary axis to measure the tibial slope, but technology-assisted knee replacement operations determine the slope in a different way. The investigators retrospectively reviewed preoperative CT scans from 40 TKA procedures and reconstructed the 3-D geometry of the tibia and fibula to determine the slope based on the intramedullary axis. They determined that in many cases, the alternate calculation of the slope used in technology-assisted procedures resulted in a different slope in the newly implanted knee. This difference could have a negative effect on the knee’s movement and mechanics, suggesting that as more procedures are performed using robotic-assisted technology, the need to re-think implant designs to incorporate these changes is likely.

Authors: Brian P. Chalmers, MD, Fernando J. Quevedo-González, PhD, Michael P. Ast, MD, Steven B. Haas, MD.

The Initial Fixation of Cementless TKA Is Associated with the AP Translation During Gait: A Computational Study

The two main goals of TKA surgery are restoring the motion of the knee joint to as close to a native knee as possible, and ensuring that the implant is properly attached to the bone so that it lasts as long as possible and does not loosen. A novel study led by Jonathan Glenday, PhD, a postdoctoral fellow, and Fernando J. Quevedo-González, PhD, assistant scientist, both in the Department of Biomechanics at HSS, looked at the intricate relationship between attachment to the bone and joint motion, and how these two aspects of joint mechanics are related. The investigators used a computational model that included gait mechanics and anatomic information from CT scans to look at whether the anterior-posterior (AP) translation (front-to-back movement) of the femur with respect to the tibia while walking was correlated with bone-implant micromotion after surgery. Based on their models, they determined that the AP translation significantly related to the peak micromotion throughout gait, especially in the lateral portion of the knee; greater AP translation resulted in larger micromotions. This study highlights the connection between joint-level mechanics and fixation-level mechanics in TKA surgery and is the first time researchers at HSS have been able to look at both in tandem.

Authors: Jonathan Glenday, PhD, Peter K. Sculco, MD, Jonathan M. Vigdorchik, MD, Joseph D. Lipman, MS, Cynthia Kahlenberg, MD, David J. Mayman, MD, Timothy M. Wright, PhD,  Fernando J. Quevedo-González, PhD.

Three-Dimensional Functional Impingement in Total Hip Arthroplasty: A Biomechanical Analysis

Impingement after THA can lead to pain and, in the worst case, a dislocation of the prosthesis. Offset of components, which is related to the width of the hip, directly affects the impingement of the hip after surgery. Surgeons have multiple ways to alter offset during THA surgery; however, these alterations have only been studied in two dimensions. A team led by HSS hip and knee surgeon Jonathan M. Vigdorchik, MD, and former clinical fellow Eytan Debbi, MD, PhD, used 3-D models created from pre- and postoperative CT scans of 16 patients who underwent the procedure to retrospectively analyze the relationship between offset and impingement. They compared cup/liner (acetabular) offset to head/stem (femoral) offsets and looked at the effects that these configurations had on the patient’s range of motion and incidence of impingement after surgery. The investigators found that in all cases, increasing the offset reduced the amount of impingement, and increased the full range of motion of the hip. Acetabular offsets had greater impact than femoral offsets in the range of motion because they affect the offset of the center-of-rotation.

Authors: Eytan Debbi, MD, PhD (Cedars-Sinai), Fernando J. Quevedo-González, PhD, Seth A. Jerabek, MD, Timothy M. Wright, PhD, Jonathan M. Vigdorchik, MD.

HSS is the world’s largest academic medical center specialized in musculoskeletal health, spanning orthopedics, rheumatology and related disciplines. The HSS Research Institute maintains 20 laboratories dedicated to solving debilitating orthopedic and rheumatic conditions such as arthritis, bone and soft tissue injuries, autoimmune diseases, and musculoskeletal pain and deformities. There, more than 300 dedicated personnel focus on tissue repair, improving surgical outcomes, autoimmunity and inflammation, genomics, new treatments, and precision medicine.

“HSS has a long history of contributing to the collective base of clinical and basic science knowledge and finding healthcare solutions for complex conditions,” said Louis A. Shapiro, President and CEO, HSS. “We’re proud that through the joint efforts of our institution and philanthropic support, we will have the ability to make a strong impact on this growing and vital area of research.”

“As experts in inflammatory disorders and in the development of interventions for overactive immune responses, the clinicians and researchers at HSS are well-positioned to investigate many of the adverse effects of COVID-19,” says Lionel B. Ivashkiv, MD, Chief Scientific Officer at the HSS Research Institute. “This includes studying the causes of these adverse effects as well as how to prevent and treat them.”What follows are descriptions of the first group of funded projects in basic/translational research:

Activation of pDCs by SARS-CoV-2 and Its Impact on Macrophage Response

Principal Investigator: Franck Barrat, PhD

Co-Investigator: Marie-Dominique Ah Kioon, PhD

This project will study cell types that are responsible for cytokine storm syndrome — the hyperactive immune response seen in people with COVID-19 — by looking at how certain immune cells are activated by SARS-CoV-2. Research in mice infected with SARS-CoV, a coronavirus similar to the one that causes COVID-19, has suggested that plasmacytoid dendritic cell precursors (pDCs) are key to the immune response to infection. These pDCs activate macrophages, which in turn secrete cytokines. In the SARS-CoV research, depletion of pDCs appeared to protect the mice from lethal lung injury. Using blood samples from donors, the investigators will study the pathway by which pDCs activate macrophages and look at ways to therapeutically block that process.

Inhibiting RNA Polymerase II Transcription Complexes in Macrophages to Target COVID-19–Associated Cytokine Storm

Principal Investigator: Inez Rogatsky, PhD

Co-Investigators: Steven Josefowicz, PhD, and Robert P. Fisher, MD, PhD

This pilot project will dissect the role of macrophages in SARS-CoV-2-induced acute respiratory distress syndrome (ARDS), the main driver of COVID-19-associated mortality. We will test small-molecule inhibitors of RNA Polymerase II (Pol II) transcription complexes for their ability to modulate type I interferon and inflammatory pathways in monocytes/macrophages. This research will be done using cultured macrophages as well as donor blood and blood from COVID-19 patients.

Mechanisms of Cytokine Storm in Patients with COVID-19

Principal Investigator: Mary K. Crow, MD

Co-Investigators: Mikhail Olferiev, MD, and Lionel B. Ivashkiv, MD

The objectives of this study are to describe the process of the cytokine storm in people with COVID-19 and to identify biologic predictors of a favorable outcome in patients with severe cases of the disease. The project aims to characterize immune cell populations seen in COVID-19 patients who experience cytokine storm and compare them to those patients who do not, to compare the immune response before and after patients are given the anti-inflammatory drug anakinra, and to identify measures that suggest patients are more likely to decline and eventually require mechanical ventilation. The research will employ blood samples from HSS patients who are being treated for COVID-19 at New York–Presbyterian Hospital and who meet certain other qualifications.

What follows are descriptions of the first group of funded projects in the areas of clinical and health outcomes research:

Response to and Recovery from TKA in Patients with Antibodies to SARS-CoV-2

Principal Investigator: Miguel Otero, PhD

Co-Investigators: Meghan Kirksey, MD, PhD, and Peter K. Sculco, MD

It is unknown if people who have been exposed to COVID-19 may be at higher risk of experiencing an abnormal immune response following surgery, resulting in poor outcomes. This study will evaluate the response to and recovery from total knee arthroplasty (TKA) in people who have antibodies to COVID-19 — a marker of exposure. This study will include both patients who have COVID-19 antibodies and those who don’t, to act as controls. Patients will be followed for six weeks after surgery and evaluated for the presence of certain immune markers in the blood, as well as symptoms of inflammation including pain and stiffness in the joint.

SARS-CoV-2 Exposure and the Role of Vitamin D Among Hospital Employees

Principal Investigator: Emily M. Stein, MD, MS

Co-Investigators: Theresa T. Lu, MD, PhD; Andy O. Miller, MD; Jeri Nieves, PhD; and Alana Serota, MD

It is unknown if people with vitamin D deficiency may be more likely to become infected with COVID-19. This study will investigate vitamin D status and associated immune markers as risk factors for COVID-19 infection in a cohort of healthcare workers. Healthcare workers are at higher risk of contracting COVID-19 than the general population, making them a good group to study. Vitamin D is critical for immune function and is known to be protective against respiratory-tract infection and tuberculosis. This prospective, observational study will follow healthcare workers at HSS and at other healthcare facilities for one year, to determine whether levels of vitamin D and certain immune cells in the blood make someone more susceptible to COVID-19 infection.

Association of Immunomodulatory Medication Use and Social Determinants of Health with COVID-19 Infection in Systemic Rheumatic Disease Patients in New York City

Principal Investigator: Medha Barbhaiya, MD, MPH

Co-Investigators from HSS: Lisa Mandl, MD, MPH; Catherine MacLean, MD, PhD; Vinicius Antao, MD, PhD; Jane Salmon, MD; and Mayu Sasaki, MPH

Other Co-Investigators: Candace Feldman, MD, MPH (of Brigham and Women’s Hospital); Debra D’Angelo, MS (of Weill Cornell Medicine)

Using data from the INSIGHT Clinical Research Network, a central repository containing longitudinal electronic health data for residents of New York City, investigators will assemble a cohort of patients being treated with immunomodulatory medications for rheumatic disease. This patient population will then be used to study the effect of these medications on COVID-19 incidence and outcomes. Retrospective data will be used to evaluate the incidence and severity of COVID-19 in these patients. Patients will also be studied prospectively to determine whether there’s a relationship between COVID-19 infection and future rheumatic disease as well as to study connections between infection and future psycho-social issues.

Assessment of Surgical Outcomes in the COVID-19 Pandemic Era

Principal Investigator: Andy O. Miller, MD

Co-Investigators: Scott A. Rodeo, MD, and Mark Fontana, PhD

Investigators will implement a patient registry to evaluate how COVID-19 affects outcomes and complication rates after orthopedic surgery. This registry, along with COVID-19 screening procedures, will provide the tools to address specific research questions. Among these questions are determining the incidence of current and prior infection among the HSS surgical population, the clinical features associated with current and prior infections in this patient population, and whether COVID-19 status affects short-term complication rates.

What follows is a description of an integrated multidisciplinary study being undertaken jointly by the Adult Reconstruction and Joint Replacement (ARJR) Perioperative Research Group, Anesthesiology and Rheumatology:

Prediction and Prevention of Postoperative Blood Clots in COVID-19 Patients

Principal Investigators: Friedrich Boettner, MD; Kethy M. Jules-Elysee, MD; Lisa A. Mandl, MD, MPH

Co-Investigators: ARJR surgeons: Alejandro Gonzalez Della Valle, MD; Jason Blevins, MD; David J. Mayman, MD; Peter K. Sculco, MD; Geoffrey H. Westrich, MD and Thomas P. Sculco, MD

Medicine/Rheumatology: Medha Barbhaiya, MD, MPH; Doruk Erkan, MD, MPH; Deanna Jannat-Khah, DrPH

Pathology: Thomas W. Bauer, MD, PhD

Anesthesiology: Stavros G. Memtsoudis, MD, PhD, MBA; Alexandra Sideris, PhD

ARJR: Amethia Joseph, MHA; Ethan Krell, MS

Weill Cornell Medicine: Raymond David Pastore, MD

Recent literature suggests that one of the major complications seen in people with COVID-19 is thrombosis (the formation of blood clots) due to endothelial dysfunction, persistent inflammation and potentially antiphospholipid antibodies. As elective surgeries resume, those with prior exposure to SARS-CoV-2 will inevitably present for treatment, and some may have perioperative management considerations related to their risk of deep-vein thrombosis. This project will use, a noninvasive device that can determine clotting risks, to investigate whether people who have had COVID-19 have a more dysfunctional endothelium preoperatively and at 24 hours after surgery. The investigators will measure antiphospholipid antibodies and inflammatory markers, and evaluate the prevalence of asymptomatic post-operative deep-vein thrombosis in people who undergo TKR and have SARS-CoV-2 antibodies.

COVID-19 Translational Research Core at HSS

Principal Investigator: Theresa Lu, MD, PhD

Co-Investigators: Jessica Andrés-Bergós, PhD; Miguel Otero, PhD and Emily M. Stein, MD, MS

The COVID-19 Translational Research Core (TRC) was designed to fill critical gaps in the resources needed to promote the broad range of COVID-19–related clinical and translational research at HSS. The TRC will provide consultation on the design and implementation of COVID-19 research in the areas of orthopedics, rheumatology and metabolic bone disease; support for a COVID-19 biobank; and technical expertise and facilities required for clinical and translational researchers working on COVID-19–related projects. The TRC staff will help to acquire, house, and track biospecimens from investigator-initiated COVID-19–related research studies.

According to the article, the system is used during total knee arthroplasty procedures.

Read the full article at beckersspine.com.

Findings indicated that patients who received amino acid prior to and after surgery performed better postoperatively.

"Supplementation of amino acid prior to and for the first 2 weeks after surgery is a safe and easy way to improve patient recovery after surgery. It should be considered as part of your perioperative management in total knee replacement," said Dr. Mayman, who presented the study at the annual meeting of the American Academy of Orthopaedic Surgeons (AAOS) this week.

Read the full article at healio.com [registration required].